Publications

PubMed

April 2018 (68 publications):

Ellis SR, Paine MRL, Eijkel GB, Pauling JK, Husen P, Jervelund M, Hermansson M, Ejsing CS#, Heeren RMA#.
Automated, Parallel Mass Spectrometry Imaging and Structural Identification of Lipids.
Nat Methods 2018. #corresponding authors.

Ouahoud S, Fiet MD, Martinez-Montanes F, Ejsing CS, Kuss O, Roden M, Markgraf DF.
Lipid droplet consumption is functionally coupled to vacuole homeostasis independent of lipophagy
J Cell Sci. 2018.

Teixeira V, Johnsen L, Martínez-Montañés F, Grippa A, Buxó L, Idrissi FZ, Ejsing CS, Carvalho P.
Regulation of lipid droplets by metabolically controlled Ldo isoforms.
J Cell Biol. 2018 217(1):127-138.

Gallego SF, Højlund K, Ejsing CS.
Easy, Fast, and Reproducible Quantification of Cholesterol and Other Lipids in Human Plasma by Combined High Resolution MSX and FTMS Analysis.
J Am Soc Mass Spectrom. 2018 29(1):34-41.

Pauling JK, Hermansson M, Hartler J, Christiansen K, Gallego SF, Peng B, Ahrends R, Ejsing CS.
Proposal for a common nomenclature for fragment ions in mass spectra of lipids.
PLoS One. 2017 12(11):e0188394.

Liebisch G, Ekroos K, Hermansson M, Ejsing CS.
Reporting of lipidomics data should be standardized.
Biochim Biophys Acta. 2017 S1388-1981(17)30037-9.

Harvald EB, Sprenger RR, Dall KB, Ejsing CS, Nielsen R, Mandrup S, Murillo AB, Larance M, Gartner A, Lamond AI, Færgeman NJ.
Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans.
Cell Syst. 2017 5(1):38-52.e4.

Yofe I, Soliman K, Chuartzman SG, Morgan B, Weill U, Yifrach E, Dick TP, Cooper SJ, Ejsing CS, Schuldiner M, Zalckvar E, Thoms S.
Pex35 is a regulator of peroxisome abundance.
J Cell Sci. 2017 130(4):791-804.

Gallego SF, Sprenger RR, Neess D, Pauling JK, Færgeman NJ, Ejsing CS.
Quantitative lipidomics reveals age-dependent perturbations of whole-body lipid metabolism in ACBP deficient mice.
Biochim Biophys Acta. 2017 1862(2):145-155.

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing CS, Zechner R, Cravatt BF, Farese RV Jr, Walther TC.
Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
J Lipid Res. 2017 58(1):226-235.

Ernst R, Ejsing CS, Antonny B.
Homeoviscous Adaptation and the Regulation of Membrane Lipids.
J Mol Biol. 2016 428(24 Pt A):4776-4791.

Rovillos MJ, Pauling JK, Hannibal-Bach HK, Vionnet C, Conzelmann A, Ejsing CS.
Structural characterization of suppressor lipids by high-resolution mass spectrometry.
Rapid Commun Mass Spectrom. 2016 30(20):2215-27.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.
Seipin is required for converting nascent to mature lipid droplets.
Elife. 2016 doi: 10.7554/eLife.16582.

Burr R, Stewart EV, Shao W, Zhao S, Hannibal-Bach HK, Ejsing CS, Espenshade PJ.
Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
J Biol Chem. 2016 291(23):12171-83.

Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T.
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.
J Med Chem. 2016 59(6):2841-6.

Mallela SK, Almeida R, Ejsing CS, Conzelmann A.
Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae.
PLoS One. 2016 11(1):e0145831.

Ejsing CS#, Bilgin M, Fabregat A.
Quantitative profiling of long-chain bases by mass tagging and parallel reaction monitoring.
PLoS One. 2015 10(12):e0144817. #corresponding author.

Liebisch G, Ejsing CS, Ekroos K.
Identification and Annotation of Lipid Species in Metabolomics Studies Need Improvement.
Clin Chem. 2015 (12):1542-4.

Voynova NS, Roubaty C, Vazquez HM, Mallela SK, Ejsing CS, Conzelmann A.
Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated.
Eukaryot Cell. 2015 14(12):1203-16.

Hansen ML, Clausen A, Ejsing CS, Risbo J.
Modulation of the Lactobacillus acidophilus La-5 lipidome by different growth conditions.
Microbiology. 2015 161(10):1990-8.

Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC.
The GARP complex is required for cellular sphingolipid homeostasis.
Elife. 2015 doi: 10.7554/eLife.08712.

Jensen SM, Neesgaard VL, Skjoldbjerg SL, Brandl M, Ejsing CS, Treusch AH.
The Effects of Temperature and Growth Phase on the Lipidomes of Sulfolobus islandicus and Sulfolobus tokodaii.
Life 2015 5(3):1539-66.

Christiansen E, Watterson KR, Stocker CJ, Sokol E, Jenkins L, Simon K, Grundmann M, Petersen RK, Wargent ET, Hudson BD, Kostenis E, Ejsing CS, Cawthorne MA, Milligan G, Ulven T.
Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases.
Br J Nutr. 2015 113(11):1677-88.

Sokol E, Ulven T, Færgeman NJ, Ejsing CS.
Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MS(ALL).
Eur J Lipid Sci Technol. 2015 117(6):751-759.

Casanovas A, Sprenger RR, Tarasov K, Ruckerbauer DE, Hannibal-Bach HK, Zanghellini J, Jensen ON, Ejsing CS.
Quantitative analysis of proteome and lipidome dynamics reveals functional regulation of global lipid metabolism.
Chem Biol. 2015 22(3):412-25.

Jensen SM, Brandl M, Treusch AH, Ejsing CS.
Structural characterization of ether lipids from the archaeon Sulfolobus islandicus by high-resolution shotgun lipidomics.
J Mass Spectrom. 2015 50(3):476-8.

Sokol E, Ulven T, Færgeman NJ, Ejsing CS.
Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MSALL.
Eur J Lipid Sci Technol. 2015 117(6):751-759

Olson DK, Fröhlich F, Christiano R, Hannibal-Bach HK, Ejsing CS, Walther TC.
Rom2-dependent phosphorylation of Elo2 controls the abundance of very long chain fatty acids.
J Biol Chem. 2015 290(7):4238-47.

Almeida R, Berzina Z, Arnspang EC, Baumgart J, Vogt J, Nitsch R, Ejsing CS.
Quantitative spatial analysis of the mouse brain lipidome by pressurized liquid extraction surface analysis.
Anal Chem. 2015 87(3):1749-56.

Almeida R, Pauling JK, Sokol E, Hannibal-Bach HK, Ejsing CS.
Comprehensive lipidome analysis by shotgun lipidomics on a hybrid quadrupole-orbitrap-linear ion trap mass spectrometer.
J Am Soc Mass Spectrom. 2015 26(1):133-48.

Casanovas A, Hannibal-Bach HK, Jensen ON, Ejsing CS.
Shotgun lipidomic analysis of chemically sulfated sterols compromises analytical sensitivity: Recommendation for large-scale global lipidome analysis.
Eur J Lipid Sci Technol. 2014 116(12):1618–1620.

Moessinger C, Klizaite K, Steinhagen A, Philippou-Massier J, Shevchenko A, Hoch M, Ejsing CS, Thiele C.
Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage.
BMC Cell Biol. 2014 Dec 10;15(1):43.

Voynova NS, Mallela SK, Vazquez HM, Cerantola V, Sonderegger M, Knudsen J, Ejsing CS, Conzelmann A.
Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.
FEMS Yeast Res. 2014 14(5):776-88.

Tarasov K, Stefanko A, Casanovas A, Surma MA, Berzina Z, Hannibal-Bach HK, Ekroos K, Ejsing CS.
High-content screening of yeast mutant libraries by shotgun lipidomics.
Mol Biosyst. 2014 10(6):1364-76.

Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA.
An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER.
Cell Rep. 2014 6(1):44-55.

Husen P, Tarasov K, Katafiasz M, Sokol E, Vogt J, Baumgart J, Nitsch R, Ekroos K, Ejsing CS.
Analysis of lipid experiments (ALEX): a software framework for analysis of high-resolution shotgun lipidomics data.
PLoS One. 2013 8(11):e79736.

Petersen NH, Olsen OD, Groth-Pedersen L, Ellegaard AM, Bilgin M, Redmer S, Ostenfeld MS, Ulanet D, Dovmark TH, Lønborg A, Vindeløv SD, Hanahan D, Arenz C, Ejsing CS, Kirkegaard T, Rohde M, Nylandsted J, Jäättelä M.
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
Cancer Cell. 2013 24(3):379-93.

Sokol E, Almeida R, Hannibal-Bach HK, Kotowska D, Vogt J, Baumgart J, Kristiansen K, Nitsch R, Knudsen J, Ejsing CS.
Profiling of lipid species by normal-phase liquid chromatography, nanoelectrospray ionization, and ion trap-orbitrap mass spectrometry.
Anal Biochem. 2013 443(1):88-96.

Foresti O, Ruggiano A, Hannibal-Bach HK, Ejsing CS, Carvalho P.
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.
Elife. 2013 2:e00953

Mosbech MB, Kruse R, Harvald EB, Olsen AS, Gallego SF, Hannibal-Bach HK, Ejsing CS, Færgeman NJ.
Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans.
PLoS One. 2013 8(7):e70087

Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R Jr, Simons K, Krogan NJ, Ernst R.
A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress.
Mol Cell. 2013 51(4):519-30

Bernardino de la Serna J, Hansen S, Berzina Z, Simonsen AC, Hannibal-Bach HK, Knudsen J, Ejsing CS, Bagatolli LA.
Compositional and structural characterization of monolayers and bilayers composed of native pulmonary surfactant from wild type mice.
Biochim Biophys Acta. 2013 1828(11):2450-2459

Duelund L, Jensen GV, Hannibal-Bach HK, Ejsing CS, Pedersen JS, Pakkanen KI, Ipsen JH
Composition, structure and properties of POPC-triolein mixtures. Evidence of triglyceride domains in phospholipid bilayers.
Biochim Biophys Acta. 2013 1828(8):1909-17

Voynova NS, Vionnet C, Ejsing CS, Conzelmann A.
A novel pathway of ceramide metabolism in Saccharomyces cerevisiae.
Biochem J. 2012 447(1):103-14.

Ejsing CS#, Husen P, Tarasov K.
Lipid informatics: from a mass spectrum to interactomics.
Book chapter in “Lipidomics – Technologies and Applications” (Wiley-VCH), 2012. *corresponding author.

Nguyen T, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM.
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance.
Traffic. 2012 13(6):880-90

Kuerschner L, Richter D, Hannibal-Bach HK, Gaebler A, Shevchenko A, Ejsing CS, Thiele C.
Exogenous ether lipids predominantly target mitochondria.
PLoS One. 2012 7(2):e31342.

Cheon SA, Bal J, Song Y, Hwang HM, Kim AR, Kang WK, Kang HA, Hannibal-Bach HK, Knudsen J, Ejsing CS, Kim JY.
Distinct roles of two ceramide synthases, CaLag1p and CaLac1p, in the morphogenesis of Candida albicans.
Mol Microbiol. 2012 83(4):728-45.

Bilgin M, Markgraf DF, Duchoslav E, Knudsen J, Jensen ON, de Kroon AIPM, Ejsing CS.
Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: a tool for monitoring PE metabolism.
Biochim Biophys Acta. 2011 1811(12): 1081-89.

Surma MA, Klose C, Klemm RW, Ejsing CS, Simons K.
Generic sorting of raft lipids into secretory vesicles in yeast.
Traffic. 2011 12(9):1139-47.

Scholz C, Parcej D, Ejsing CS, Robenek H, Urbatsch IL, Tampe R
Transporter associated with antigen processing (TAP) is modulated by lipids.
J Biol Chem. 2011 286(15):13346-56.

Sampaio JL, Gerl MJ, Klose C, Ejsing CS, Beug H, Simons K, Shevchenko A.
Membrane lipidome of an epithelial cell line.
Proc Natl Acad Sci U S A. 2011 108(5):1903-7.

Vionnet C, Roubaty C, Ejsing CS, Knudsen J, Conzelmann A.
Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors.
J Biol Chem. 2011 286(8):6769-79.

Klose C, Ejsing CS, García-Sáez AJ, Kaiser HJ, Sampaio JL, Surma MA, Shevchenko A, Schwille P, Simons K.
Yeast lipids can phase-separate into micrometer-scale membrane domains.
J Biol Chem. 2010 285(39):30224-32.

Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC.
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking.
Nat Struct Mol Biol. 2010 17(7):901-8.

Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS.
Orm family proteins mediate sphingolipid homeostasis.
Nature 2010 463(7284):1048-53.

Le Guédard M, Bessoule JJ, Boyer V, Ayciriex S, Velours G, Kulik W, Ejsing CS, Shevchenko A, Coulon D, Lessire R, Testet E.
PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast.
FEBS J. 2009 276(21):6412-24.

Kalvodova L, Sampaio JL, Cordo S, Ejsing CS, Shevchenko A, Simons K.
The lipidomes of vesicular stomatitis virus, semliki forest virus, and the host plasma membrane analyzed by quantitative shotgun mass spectrometry.
J Virol. 2009 83(16):7996-8003.

Klemm RW*, Ejsing CS*, Surma MA, Kaiser HJ, Gerl MJ, Sampaio JL, de Robillard Q, Ferguson C, Proszynski TJ, Shevchenko A, Simons K.
Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network.
J Cell Biol. 2009 185(4):601-12. *equal contribution.

Ståhlman M*, Ejsing CS*, Tarasov K, Perman J, Borén J, Ekroos K.
High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 877(26):2664-72. *equal contribution.

Zech T*, Ejsing CS*, Gaus K, de Wet B, Shevchenko A, Simons K, Harder T.
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling.
EMBO J. 2009 28(5):466-76. *equal contribution.

Ejsing CS#, Sampaio JL, Surendranath V, Duchoslav E, Ekroos K, Klemm RW, Simons K, Shevchenko A#.
Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry.
Proc Natl Acad Sci U S A. 2009 106(7):2136-41. #corresponding authors.

Tsai CJ, Ejsing CS, Shevchenko A, Ziegler C.
The role of lipids and salts in two-dimensional crystallization of the glycine-betaine transporter BetP from Corynebacterium glutamicum.
J Struct Biol. 2007 160(3):275-86.

Ozcan N, Ejsing CS, Shevchenko A, Lipski A, Morbach S, Krämer R.
Osmolality, temperature, and membrane lipid composition modulate the activity of betaine transporter BetP in Corynebacterium glutamicum.
J Bacteriol. 2007 189(20):7485-96.

Ejsing CS, Duchoslav E, Sampaio J, Simons K, Bonner R, Thiele C, Ekroos K, Shevchenko A.
Automated identification and quantification of glycerophospholipid molecular species by multiple precursor ion scanning.
Anal Chem. 2006 78(17):6202-14.

Ejsing CS, Moehring T, Bahr U, Duchoslav E, Karas M, Simons K, Shevchenko A.
Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry.
J Mass Spectrom. 2006 41(3):372-89.

Schwudke D, Oegema J, Burton L, Entchev E, Hannich JT, Ejsing CS, Kurzchalia T, Shevchenko.
Lipid profiling by multiple precursor and neutral loss scanning driven by the data-dependent acquisition.
Anal Chem. 2006 78(2):585-95.

Kuerschner L, Ejsing CS, Ekroos K, Shevchenko A, Anderson KI, Thiele C.
Polyene-lipids: a new tool to image lipids.
Nat Methods. 2005 2(1):39-45

Ekroos K*, Ejsing CS*, Bahr U, Karas M, Simons K, Shevchenko A.
Charting molecular composition of phosphatidylcholines by fatty acid scanning and ion trap MS3 fragmentation.
J Lipid Res. 2003 44(11):2181-92. *equal contribution.